CommentaryOpen Access

Retinal changes in Alzheimer's disease: Disease Mechanisms to Evaluation perspectives.

M Mirzaei1,2,3 *, V B Gupta4, V K Gupta2

1Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia

2Department of Clinical Medicine, Macquarie University, Sydney, NSW, Australia

3Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW, Australia

4School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia

For the past decade the concept of “the eye as a window to brain” is increasingly being explored to understand brain functioning in health and disease conditions. During embryonic development, the retina and optic nerve project from the telencephalic and hypothalamic fields, and are thus considered part of the central nervous system (CNS)1,2. Retinal tissue demonstrates multiple similarities with the brain tissue at the cellular and biochemical levels. Further, similar to the blood-brain barrier, retinal tissue maintains a distinct immune environment that is facilitated by the blood-retinal barrier3. Several endogenous mechanisms have been identified in the retina that protect the tissue from non?specific damage linked with the immune responses4,5. A distinctive milieu comprising of glial cells, surface molecules and cytokines imparts an ability to perform specialized immune responses similar to that observed in the brain and spinal cord tissues6. The limitations of brain imaging such as capturing fluorescence signals through the skull, invasive nature of accessing CSF fluid and high costs involved in MRI and PET scans necessitate exploring alternative options and in this aspect retinal imaging may serve as surrogate marker of monitoring various brain diseases and understand their effects on the eyes.

With the advances in optical coherence tomography (OCT) and OCT angiography for the retina, both animal and human retinas can be assessed for experimental or disease associated differences in vivo. Retina is increasingly being investigated to study the effects of predominantly brain related pathological conditions such Alzheimer’s disease (AD)7, Parkinson’s disease8, Multiple sclerosis9 and most recently Amyotrophic lateral sclerosis (ALS)10.

Extracellular deposits and aggregates containing amyloid β (Aβ) and intracellular neurofibrillary tangles composed of hyper-phosphorylated tau have been observed in the retina in animal models of AD7,11. Partial overlap of such molecular changes has also been reported in retinal neurodegenerative disorders such as age related macular degeneration (AMD) and glaucoma conditions12-15.

Clinically, AD patients exhibit a progressive decline in memory and impaired cognition and learning abilities, which are accompanied by visual and ocular manifestations, such as impaired pupil response, contrast sensitivity, thinning of retinal layers and decreased visual function13,16. Studies also suggest an increased incidence of glaucoma pathology in AD patients, which indicates a genetic or pathological link between the two disorders that either predisposes AD subjects to glaucoma or exacerbates the glaucoma pathology17,18. Another possibility is the manifestation of AD effects in a way that overlaps with glaucoma associated pathological changes in the retina and optic nerve. Detailed clinical and animal studies in pre-clinical stages and post-AD development stages will help to elucidate the similarities and differences in terms of ocular effects between the two disorders and understand the extent of overlap. A link between the two diseases is also suggested because both the diseases affect predominantly the inner retinal function and structure. Detailed analysis of the imaging changes in central and peripheral regions of the retina along with clinical assessment will help unravel the differential effects of the two disorders on the retina and optic nerve.

Studies in AD patients and animal models of AD such as in APP/PS1 and TG2576 mice models demonstrate retinal nerve fibre layer thinning and loss of the retinal ganglion cells (RGCs), which is also a hallmark of glaucoma7,19. Furthermore, increased Aβ levels and tau hyperphosphorylation has been identified in both AD as well as in glaucoma retinas20. Targeting Aβ peptide using specific antibodies in glaucoma mice protected against the retinal ganglion cell loss and apoptosis, indicating a pathological role of this protein21. Awareness of the Aβ accumulation in the retinas of AD subjects and AD animal models has led to an increasing body of work exploring biochemical mechanisms and a prospective biomarker role for retinal changes in AD.

Future studies will need to identify retinal changes that are specifically associated with AD pathology and can be effectively distinguished from the retinal deficits observed in glaucoma, AMD and ageing. Potential retinal changes if identified in early stages of AD may play a critical role in improving the disease diagnosis. In more established cases of AD, ocular deficits may be used for non-invasive monitoring of the disease. For example, OCT imaging has revealed reduced peripapillary RNFL thickness in AD patients, with thinning of average, superior and inferior GCL compared to the control subjects22-24. Further, detailed analysis of macular quadrants has indicated significantly reduced macular volume as well as loss of the nasal, temporal and inferior region thickness in AD25,26. Retinal imaging studies in larger cohorts of healthy ageing and potential AD subjects demonstrating mild cognitive impairment (MCI) will be helpful to identify biological markers for early diagnosis of the disease and for monitoring the disease progression. Changes in RNFL thickness have previously been reported in MCI subjects by different groups27,28. The molecular changes in the retina and optic nerve at different stages of AD will also provide us useful clues about the way various proteins and biochemical pathways are affected in various stages of disease. This information will help in targeted discovery of alterations in various proteins and molecular networks as a marker of the disease in accessible body fluids. These changes could be associated with either protein expression changes or post-translational modifications, which could then affect various cellular signalling pathways. It is important to highlight that these changes may show a direct correlation with brain pathology linked with AD or may be independent of these changes, but regardless will help to understand the novel mechanisms at the fore-front of AD pathology. Further, every case of AD is different and there may be significant variations between sporadic versus familial types of AD as well as with vascular dementias. We may also hope to expect significant differences in ocular effects of the disease with respect to sex, age and ethnicities. As AD is associated with a wide range of clinical presentations- with the technological advancements neuroscientists and neurologists could truly hope to develop a spectrum of retinal changes connected to AD in the near future.

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Article Notes

  • Published on: March 29, 2018


  • Optical coherence tomography
  • Alzheimer's disease


Dr. Mehdi Mirzaei
Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia

©2018 Mirzaei M. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.