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The overarching goal of the Journal of Neurology and Neuromedicine is to remain as a credible source of neurological sciences based information encompassing a variety of relevant areas such as clinical studies, cellular and molecular studies, disease mechanisms, diagnostic approaches, epidemiology, medical aspects, computational studies and treatment options of the most common neurobiological complexities with an emphasis on research that is genetically, structurally, physiologically and pathophysiologically relevant.
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Uwe Ernsberger
Institute for Clinical Neuroanatomy, Johann-Wolfgang-Goethe University, Frankfurt/Main, Germany
The molecular characterization of postganglionic sympathetic neurons by RNA sequencing has allowed the full assessment of gene expression in individual cells and classification of neurons into subpopulations defined by their gene expression profile and developmental history. The identification of growth factor receptor subunits specifically expressed by select neuron subpopulations enabled the demonstration of GDNF family ligands and the respective receptor subunits as instrumental in the innervation of certain targets. These are first critical steps in the attempt to characterize the molecular processes leading to the establishment and maintenance of target-specific sympathetic efferent pathways.
DOI: 10.29245/2572.942X/2019/4.1252 View / Download Pdf View Full Text We offer editing services to help you prepare a submission-ready manuscript.
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