Diffusion Tensor Imaging to Analyze White Matter Tract Abnormalities in Major Psychiatric Disorders
Background: Diffusion Tensor Imaging (DTI) is a novel MRI technique developed for measuring the integrity of white matter and its structural connectivity within the brain. DTI captures the movement of water molecules along the neural pathways, providing valuable information on the micro-structural changes that are associated with particular neurological disorders.
Methods: This paper examines some of the concepts related to DTI and its particular indices such as fractional anisotropy (FA) and mean diffusivity (MD). DTI scanning protocols and post-processing modifications are evaluated in the context of white matter tracts abnormalities detection.
Results: The results show how DTI can reveal changes in white matter lesions which could not be perceived using routine MRI techniques. Changing values of FA and MD are associated with the level of disease progression and cognitive deficit.
Conclusion: DTI is a powerful tool for investigating white matter integrity and diagnosing neurological disorders. While it offers significant advantages in neuroimaging, further advancements in imaging acquisition and analysis techniques are needed to improve reliability and clinical utility.
DOI: 10.29245/2572.942X/2025/2.1313 View / Download PdfCommentary: Finding Relief from Chemo-Induced Peripheral Neuropathy
This commentary by a patient describes a syndrome that often develops residual to chemotherapy and yet escapes timely detection and effective treatment: chemo-induced peripheral neuropathy (CIPN). Physicians and their patients who suffer from CIPN, particularly those with unremitting small fiber neuropathy (SFN), may benefit from the evidence-based guidance provided. The author also calls for deeper listening by the medical community, interdisciplinary collaboration and patient self-advocacy.
DOI: 10.29245/2572.942X/2025/2.1314 View / Download Pdf